Development of a tissue-like protoporphyrin IX fluorescence phantom and performance of characterisation experiments
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منابع مشابه
Evaluation of Sonochemiluminescence in a Phantom in the Presence of Protoporphyrin IX Conjugated to Nanoparticles
Introduction When a liquid is irradiated with high-intensity and low-frequency ultrasound, acoustic cavitation occurs and there are some methods to determine and quantify this phenomenon. The existing methods for performing these experiments include sonochemiluminescence (SCL) and chemical dosimetric methods. The particles in a liquid decrease the ultrasonic intensity threshold needed for cavit...
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A high frequency ultrasound-coupled fluorescence tomography system, which was primarily designed for imaging protoporphyrin IX production in skin tumors in vivo, is demonstrated for the first time. Protoporphyrin IX is an endogenous, fluorescent molecule produced naturally in the heme biosynthesis pathway, with enhanced production in many cancerous tumors. The design couples non-contact fiber-b...
متن کاملSystem development for high frequency ultrasound-guided fluorescence quantification of skin layers.
A high frequency ultrasound-coupled fluorescence tomography system, primarily designed for imaging of protoporphyrin IX production in skin tumors in vivo, is demonstrated for the first time. The design couples fiber-based spectral sampling of the protoporphyrin IX fluorescence emission with high frequency ultrasound imaging, allowing thin-layer fluorescence intensities to be quantified. The sys...
متن کاملDevelopment and characterization of a brain tumor mimicking fluorescence phantom
Fluorescence guidance using 5-aminolevulinic acid (5-ALA) for brain tumor resection is a recent technique applied to the highly malignant brain tumors. Five-ALA accumulates as protoporphyrin IX fluorophore in the tumor cells in different concentrations depending on the tumor environment and cell properties. Our group has developed a fluorescence spectroscopy system used with a hand-held probe i...
متن کاملSynthesis of Two Compounds with Self-Assembled Monolayer Properties: Riboflavin 2', 3', 4' , 5' Tetra Octadecanoate & Bis (Phosphatidyl Ethanol) Protoporphyrin IX Amide
Riboflavin and protoporphyrin IX are two molecules that participate in oxidation and reduction reactions in the living cell. Changing some functional groups of riboflavin and protoporphyrin IX can provide compounds with self-assembled monolayer properties with wide applications in designing the molecular electronic devices. In this study, the amphiphilic structure of riboflavin and protopor...
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تاریخ انتشار 2013